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In specific aspects of this embodiment, the revTetR protein comprises an amino acid substitution at a position selected from the group consisting of positions number 18, 22, 20, 23, and 17 of SEQ ID NO: 32, selected from the group consisting of positions 18, 20, and 22 of SEQ ID NO: 32, and more particularly, or at position 18 of SEQ ID NO: 32.

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